Laura MacConaill, PhD presents the cumulative body of work at the Dana Farber Cancer Institute and Brigham and Women's Hospital during the conference at the Association for Molecular Pathology, November 2010.
Hypermethylation of Tumor Suppressor Genes Involved in Critical Regulatory Pathways for Developing a Blood-Based Test in Breast Cancer
This study evaluates the possibility of a blood-based test for analyzing the methylation of circulating cell-free DNA derived from tumor for the potential diagnosis and management of breast cancer patients. Using the EpiTYPER method, over 30k CpGs from ten breast cancer genes were rapidly profiled. Significant promoter hypermethylation of eight tumor suppressor genes was seen. The results suggest the potential of using cancer-specific methylation changes in plasma and serum for the development of a blood-based test as a predictive and prognostic biomarker.
Search our literature database for more key studies powered by the MassARRAY system.
* M. Ehrich, Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry. PNAS, November 1, 2005 – Vol 102, no. 44, 15785-15790
Name: AACR Annual Meeting
Date: April 2-6, 2011
Details: Come visit us at booth #215