Dr. Holzgreve graduated from the School of Medicine, the Westfälische Wilhelm University, Münster, Germany in 1975. In 1976, he earned the degree of Master of Science in Health and Medical Sciences at the University of California, Berkeley. From 1976 to 1978, he studied at the School of Medicine in Münster, Germany, and finished his residency in Obstetrics and Gynecology, Department of Obstetrics and Gynecology, University of Münster, in 1982. Between 1982 and 1984, he completed a Fellowship of the German Research Foundation in Reproductive Genetics, at the Department of Obstetrics and Gynecology and Reproductive Sciences at the University of California, San Francisco, USA. Dr. Holzgreve was Board Certified in Clinical Genetics and Obstetrics and Gynecology in 1985.
By 1991, he had risen to the rank of Professor of Obstetrics and Gynecology, Geschäftsf. Oberarzt, Department of Obstetrics and Gynecology, University of Münster. In August 1995, he moved to Switzerland to take up his present appointment as Chairman of the Department and Chief of Service at the Department of Obstetrics and Gynecology, University of Basel, from where he transitioned to his current position in Freiburg in 2009.
His publications have numbered more than 500 articles in important peer-reviewed scientific journals, 180 book chapters, 6 books, 400 abstracts at scientific meetings, and more than 400 oral presentations at postgraduate courses and seminars. Dr. Holzgreve is on the editorial board of many important journals and is a reviewer for the New England Journal of Medicine, the American Journal of Obstetrics and Gynecology, Obstetrics and Gynecology, Journal of Pediatrics, Prenatal Diagnosis, Human Genetics, Journal of Ultrasound in Obstetrics & Gynecology, American Journal of Medical Genetics, Schweizerische Medizinische Wochenschrift, Gene, and Human Reproduction. Dr. Holzgreve has also received numerous prize and awards. Dr. Holzgreve is also currently the President of the International Society "The Fetus as a Patient", the German Society of Reproductive Medicine, and the Chairman of the Scientific Committee of the World Federation of Perinatal Medicine.