DNA Methylation Analysis with EpiTYPER®
Technical Information & Downloads
DNA Methylation Software Tools
- EpiDesigner: Primer Design for Bisulfite Converted DNA
- EpiTYPER Demo: See the EpiTYPER Software in action with this narrated tutorial.
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Understanding the role DNA methylation plays in gene regulation is challenging enough, so why use tools that are laborious, inaccurate, or provide some kind of estimate of DNA methylation status to further complicate things?
There are plenty of methods out there to study DNA methylation, but only EpiTYPER will have you spending your time drafting publications rather than re-working experiments. Save yourself some time with accurate and reproducible data and Publish Faster with EpiTYPER.
DNA Methylation Analysis Simplified
Sequenom’s EpiTYPER workflow minimize the manual primer design and assay optimization that can lead to longer experimental time and unwanted variability. This carefully optimized research workflow is an ideal solution for post-array and deep sequencing validation or targeted gene promoter analysis, providing you with:
Accurate and Reproducible DNA Methylation Mapping
- Delivers individual methylation ratios for CpGs within a target sequence
- Relative methylation ratios can be assessed in a range between
10-90% with a standard deviation of 5%
Flexible DNA Methylation Experimental Design
- Scalable for investigating a few or several hundred regions over multiple samples
- Long reads up to 600 bp in one reaction enable discovery of differential methylation within large promoter regions
- Robust analysis from a range of sample types including Formalin Fixed Paraffin Embedded (FFPE) samples
Convenient Pre-Validated DNA Methylation Panels
What are Researchers Saying about EpiTYPER?
“We are successfully using SEQUENOM’s EpiTYPER for quantitative DNA methylation analysis in our comprehensive cancer center research programs. This product enables us to analyze multiple CpGs in one amplicon and to reliably compare their methylation status between individual samples. Unlike classic methods for assessing methylation events at individual sites in the genome, EpiTYPER quantitatively assesses methylation ratios simultaneously across multiple CpG sites over multiple samples dramatically increasing the scope and throughput of analysis.”
Norma J. Nowak, Ph.D.,
Associate Professor, Director, Scientific Planning
RPCI and University at Buffalo, NY |