Genetic Analysis
DNA Methylation Analysis
Applications Applications
DNA Methylation Analysis DNA Methylation Analysis
Pre-Validated DNA Methylation Assays Pre-Validated DNA Methylation Assays
Custom DNA Methylation Assays Custom DNA Methylation Assays
SNP Genotyping SNP Genotyping
Molecular Typing Molecular Typing
Rare Mutation Profiling Rare Mutation Profiling
Gene Expression Analysis Gene Expression Analysis
Research Area Research Area
Systems Systems

DNA Methylation Analysis with EpiTYPER®

DNA Methylation Software Tools
  • EpiDesigner: Primer Design  for Bisulfite Converted DNA
  • EpiTYPER Demo: See the EpiTYPER Software in action with this narrated tutorial.
SPECIAL BOOK REPRINT OFFER:
  • Sign Up Now and we'll send you chapter reprints from Springer Protocols 2nd Edition of DNA Methylation, Methods and Protocols...

Understanding the role DNA methylation plays in gene regulation is challenging enough, so why use tools that are laborious, inaccurate, or provide some kind of estimate of DNA methylation status to further complicate things?

There are plenty of methods out there to study DNA methylation, but only EpiTYPER will have you spending your time drafting publications rather than re-working experiments. Save yourself some time with accurate and reproducible data and Publish Faster with EpiTYPER.
 
DNA Methylation Analysis Simplified

Sequenom’s EpiTYPER workflow minimize the manual primer design and assay optimization that can lead to longer experimental time and unwanted variability.  This carefully optimized research workflow is an ideal solution for post-array and deep sequencing validation or targeted gene promoter analysis, providing you with:
 

Accurate and Reproducible DNA Methylation Mapping
  • Delivers individual methylation ratios for CpGs within a target sequence
  • Relative methylation ratios can be assessed in a range between
    10-90% with a standard deviation of 5%

     

Flexible DNA Methylation Experimental Design
  • Scalable for investigating a few or several hundred regions over multiple samples
  • Long reads up to 600 bp in one reaction enable discovery of differential methylation within large promoter regions
  • Robust analysis from a range of sample types including Formalin Fixed Paraffin Embedded (FFPE) samples

     

Convenient Pre-Validated DNA Methylation Panels
  • Chose from pre-validated assays in the EpiTYPER Panels
  • Design custom assays with the freely-available EpiDesigner Program
 
What are Researchers Saying about DNA Methylation Analysis wiEpiTYPER?

Norma J. Nowak speaks about EpiTYPER for quantitative DNA methylation analysis

 

“We are successfully using SEQUENOM’s EpiTYPER for quantitative DNA methylation analysis in our comprehensive cancer center research programs. This product enables us to analyze multiple CpGs in one amplicon and to reliably compare their methylation status between individual samples. Unlike classic methods for assessing methylation events at individual sites in the genome, EpiTYPER quantitatively assesses methylation ratios simultaneously across multiple CpG sites over multiple samples dramatically increasing the scope and throughput of analysis.”

 

                                          Norma J. Nowak, Ph.D.,
                                          Associate Professor, Director, Scientific Planning
                                          RPCI and University at Buffalo, NY