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Revolutionary Automation for Ultra-High-Throughput SNP Analysis
We will present a newly developed and validated automated, error-free SNP analysis platform that is completely integrated, highly reliable and features substantial cost savings. Further, this platform dramatically reduces cycle times and enables throughput capabilities of 100,000 analyses per day with full sample tracking and on-line data analysis. Novel technologies will be presented that include rapid, high-throughput, low sample volume thermal cycling; highly parallel, nanoliter sample transfer; and real-time, error-free genotype data acquisition and analysis.

A Highly Reliable Nanoliter Sample Dispensing Method for High Throughput SNP Analysis Applications
SpectroPOINT, SEQUENOM’s new nanoliter sample dispensing instrument, was built utilizing a proprietary, slotted pin design to eliminate the current bottlenecking in sample transfer process. This unique combination of this unique pin design and dispensing method assure reliable nanoliter sample delivery from MTP to chip without incurring any damage to the delicate, pre-loaded MALDI matrix. The throughput of the SpectroPOINT is approximately 6 fold higher than most standard piezo-based dispensing instrument.

High Throughput Real-Time SNP Genotype Analysis Using MALDI-TOF
To meet the demands of high-throughput SNP analysis in the post-genome era, we have developed a real-time system that enables rapid SNP genotyping on a MALDI-TOF mass spectrometer. With this development, the accuracy, analytical prowess and the reliability of mass spectroscopy has been brought to bear genotyping applications on an industrial scale.